1/12/2024 0 Comments Luminal abuse signsAlthough phenobarbital sodium powder for solution is indicated only for short-term use, if used for a longer duration than recommended, abrupt discontinuation or rapid dosage reduction of phenobarbital sodium powder for solution may precipitate acute withdrawal reactions, which can be life-threatening. The risks of dependence and withdrawal increase with longer treatment duration and higher daily dose. ![]() If a decision is made for concomitant use of these drugs, limit dosages and durations to the minimum required, and follow patients for signs and symptoms of respiratory depression and sedation.Dependence and Withdrawal Reactions After Use of Phenobarbital Sodium Powder for Solution for a Longer Duration than RecommendedThe continued use of phenobarbital may lead to clinically significant physical dependence. ![]() Reserve concomitant prescribing of these drugs for patients whom alternative treatment options are inadequate. Risks from Concomitant Use with OpioidsConcomitant use of phenobarbital products including phenobarbital sodium powder for solution, and opioids, may result in profound sedation, respiratory depression, coma, and death.
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